The Eldepryl drug is used to treat patients with diseases such as symptomatic parkinsonism and Parkinson’s disease. On the virtue of the compound of the drug, it can be used as a monotherapeutic drug in the initial stages of the development of Parkinson’s disease. With the help of timely detection of this disease, the drug allows delaying the use of levodopa. Also, it can be used in conjunction with it.
The drug is used exclusively to combat this disease and is prescribed only by the attending physician by confirmation of the diagnosis. This drug is not intended for self-prescription, treatment of other diseases and dosage adjustment.
It is worth paying attention to the fact that there are no data that confirm the positive effect of the drug in the absence of joint therapy with levodopa.
How Does Eldepryl Work
There are two types of mitochondrial monoamine oxidase enzymes, MAO-A and MAO-B. The substrate of these enzymes is different. MAO-A mainly breaks down serotonin, norepinephrine, and epinephrine, while MAO-B breaks down mainly phenylethylamine. Dopamine is cleaved by both enzymes. Both enzymes are distributed unequally in the body: MAO-B is mostly found in the brain. This drug selectively and irreversibly inhibits MAO-B.
Moreover, this inhibitor works quite well at the level of the nerve endings and therefore has an inhibitory effect on presynaptic dopamine receptors. Reducing the number of dopaminergic neurons in the nigra striped substance is the pathological basis of Parkinson’s disease.
By inhibiting MAO-B, the drug increases dopamine levels and, together with levodopa, ensures its high concentration in the area of nigra striped substance. The drug can increase the effect of levodopa, thus reducing the required dose of levodopa, reducing the latent period for the development of a fruitful force, prolonged the duration of action. Since the proposed doses do not inhibit the metabolism of other monoamine oxidases, hypertensive reactions are excluded during treatment.
Contraindications to Intake This Drug
The drug is prohibited for use in patients with the following symptoms:
Hypersensitivity to any of the components of the drug.
The presence of extrapyramidal disorders that are not associated with dopamine deficiency (essential tremor, Huntington’s chorea).
It is prohibited to use when taking antidepressants at the same time, as well as for five weeks after the cancellation of their adoption.
It is recommended not to take pills during pregnancy and lactation.
It can be allowed to take Eldepryl with extreme caution and medical supervision with:
Progressive dementia, severe psychosis, tardive dyskinesia, large-billowing tremor, peptic ulcer sweepers (including a history), thyrotoxicosis, pheochromocytoma, prostatic hyperplasia (with residual urine), closed-angle glaucoma, prostatic hyperplasia (with residual urine), age up to 18 years (It is not enough data about clinical in this age group).
When combined with levodopa: open-angle glaucoma (chronic course), hepatic and / or renal failure, melanoma (including a history), CNS depression, seizures, bronchial asthma, pulmonary emphysema, myocardial infarction (including in history, as well as in combination with atrial, nodular or ventricular arrhythmias), age up to 12 years (there is no relevant information about the influence of this medication at this age).
Provide your doctor with information about what other medicines you are using before starting treatment. Also, if you plan to cancel taking any medication or begin a course of treatment, you should also inform your doctor about this. The interaction of this drug with others can have a severe impact on the functioning of the body.
Taking the drug in patients with diabetes mellitus is possible under medical supervision and with extreme caution, as the individual components of the drug can lead to increased and prolonged hypoglycemia.
It is forbidden to take the drug in patients with diseases such as duodenal ulcer or stomach in the acute stage.
It is strictly forbidden to drink alcohol during the treatment, as well as food products that have a high content of tyramine. Tyramine in combination with the consumption of selenium can dramatically increase blood pressure and donate to the development of life-threatening symptoms.
Please note that this drug may not interact with many other medicines due to the presence of a substance such as selegiline. In addition to medication, more plant foods should also be eliminated from your diet. Don’t forget to get this information from your doctor to avoid side effects and increase treatment effectiveness.
You cannot carry out the sudden cancellation of the drug, so as not to cause worsening of side effects. Check with your doctor before discontinuing the medication.
Against the background of treatment with this drug, patients should refrain from activities that are potentially dangerous and require increased attention and speed of mental and motor responses. You must refuse to drive a car or other vehicles at the time of treatment, mainly if the drug adversely affects the speed of your reaction.
Do not give your drug to any other person, even if you have similar diseases. This can lead to life-threatening consequences for another person.
Intake and Dosage
There is a need to reduce the dosage of levodopa at the beginning of therapy with this medication. Take the drug according to the strict prescription that your doctor wrote for you. The dosage can be adjusted by the physician to enhance the effectiveness of the course of treatment depending on the individual characteristics of the patient. It is forbidden to adjust the dosage on their own both upwards and downwards. Also, it is not permitted to take the drug for longer than was established by the doctor.
This drug is taken orally, and it is recommended not to chew and drink a small amount of liquid.
If you miss a pill, it is recommended to take it as soon as possible. You can not make a double dose and make it more times than is prescribed during the day.
In combination therapy with levodopa and carbidopa, 5–10 mg is taken, which makes it possible to reduce the dose of levodopa by 10–30% per day without deterioration of the patient’s locomotor functions. Usually, this medication is taken twice a day during a meal (breakfast and lunch). The daily dose of the drug should not exceed 10 mg to avoid adverse effects.
Please note that for two weeks after discontinuation of the drug is prohibited to use many foods. Products that you can use during treatment include:
Meat food (poultry, fish, ham)
All vegetables except beans.
Dairy foods: cottage cheese, ricotta, mozzarella, and melted cheese, soy milk and yogurt.
Side effects that most often occur during medication:
Nausea, acute pain in the stomach, constipation;
Skin rash or other irritation of the skin;
Insomnia, violation of the schedule of the day.
However, there is a list of side symptoms that are not so common, but you should be informed about them if you are taking Eldepryl:
Allergic reactions: skin rash, shortness of breath, bronchospasm, photosensitization
Depression and suicidal thoughts.
Respiratory Dysfunction: Difficult Breathing.
You are clouding of consciousness: hallucinations, confusion, anxiety, unusual behavior, and thoughts.
Uncontrolled muscle contractions and increased tremor.
The drug can contribute to the development of side effects of other medicines that are used together.
The use of antidepressants increases serotonin levels, and this drug can contribute to the development of fever, rapid heart failure, and overactive reflexes of the body: nausea, vomiting, diarrhea, impaired coordination of movement, fainting.
If blood pressure rises, there can be a severe headache, blurred vision, knocking on the neck or ringing in the ears, anxiety, nausea, vomiting, severe chest pain, shortness of breath, pounding heartbeats and muscle cramps.
The drug aggravates sexual impulses, to gambling and similar actions.
In rare cases, such adverse effects as hypoglycemia, hair loss, and hyper perspiration can occur.
In the event of at least one of the above symptoms, you must urgently inform your doctor and get medical help. Revising the treatment option for this medicine is vital.
Since the drug potentiates the action of levodopa, the side effects of levodopa may increase, especially when using high doses of levodopa. In such cases, strict monitoring of the patient’s condition is necessary. The use of the drug in the treatment of levodopa can cause patients involuntary movements or strong excitement. Such side effects disappear at lower doses of levodopa.
With the simultaneous use of this drug and levodopa, the dose of levodopa can be reduced by an average of 30%.
The symptoms of an overdose may include the following conditions:
apathy and an increased feeling of irritability
acute chest pain
severe dizziness and fainting
grow in a heartbeat for an extended period without a return to full-time rhythm
changes in blood pressure
changes and difficulty breathing for an extended period.
If you have symptoms of overdose, you must urgently contact the medical institution. At the stage of early poisoning, gastric lavage is required, and there is a need for subsequent medical therapy. It should be noted that when any symptoms appear, it is necessary to measure body temperature and to monitor its changes before recovery continuously.